A recent study indicates that people who stop using blockbuster weight-loss injections like Mounjaro or Wegovy may regain shed pounds much more quickly than those who stop traditional lifestyle plans.
Research printed in a prominent health publication demonstrates that while obese people often shed a large proportion of their total mass while on the medication, the weight comes back at an average rate of nearly a kilo each month upon discontinuation.
"Users using these medications need to be aware of the risk of quick weight regain when the treatment is stopped," cautioned expert Dr. Susan Jebb.
Such speed of recovery implies a reversion to original mass within about one and a half years.
Analyzing Approaches
The analysis, which examined dozens of trials involving over 9,000 of patients, compared the effects of the injectable medications with other pills.
Scientists point out that individuals who shed pounds through dieting generally experience a slower creep back—approximately 100 grams monthly—after stopping.
Explaining the Rapid Regain
Doctors propose the mode of action of the drugs is key to understanding the accelerated weight return.
GLP-1 drugs copy a natural hormone called GLP-1, which controls appetite.
"Long-term administration of the hormone levels far above than normal could lead to the body to produce less of its own natural GLP-1, and may also reduce sensitivity to its effects," noted Dr. Adam Collins, a dietetics expert.
"Discontinuation of this hormone supplement leads to hunger is unsuppressed, making binge eating far more likely."
A Lifelong Issue?
Health authorities advise the jabs for people with weight-linked medical conditions, accompanied by recommended diet and exercise modifications.
Professionals say that, given the significant potential of relapse, the treatment is often life-long.
This opinion is echoed by pharmaceutical companies, who state that the findings "underscore the long-term character of excess weight," comparing it to managing conditions like high blood pressure.
Patient Accounts
People who have stopped the jabs report a sudden return of hunger.
"It was like a switch activating and you become extremely hungry," said a patient.
This challenge is worsened if patients have not developed sustainable dietary or behavioural modifications during treatment.
Widespread Adoption
Figures show that a significant number of people in the UK have used weight-loss jabs in the last 12 months, with desire continuing to grow.
- Use is greater among women than males.
- The 40s and 50s demographic shows the greatest usage rates.
- A large proportion access the drugs through private healthcare rather than the NHS.
In conclusion, researchers stress that while the jabs are potent agents for weight loss, they are not a permanent solution and long-term success hinges on combined lifestyle changes.
